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Pramlintide solves that with three proline substitutions at positions 25, 28 and 29, borrowed from a non-fibrillating rodent sequence, and remains amylin-receptor selective

(NICE Guideline, No

The patients suitability is a key factor as is the expertise of the professional performing the treatments

Tolerability and Safety Questions Both candidates are likely to be judged partly on gastrointestinal tolerability: nausea, vomiting, diarrhea, constipation, dose escalation, and discontinuation due to adverse events

Phentermine And Eating Disorders People with Binge Eating Disorder (BED) or bulimia nervosa may also be candidates for phentermine treatment, though this is assessed carefully on a case-by-case basis