Upregulated DETs implicated in the innate immune system included phosphatidylinositol 3-kinase catalytic subunit type 3, two mucin variants (mucin-22, mucin-4-like), autophagy-related protein 13-like, and diuretic hormone receptor isoform X1, while DETs involved in the response to stress featured alpha-crystallin A chain-like, two glutathione peroxidase-like, gamma-glutamylcyclotransferase isoform X3, and a constitutive coactivator of PPAR-gamma-like protein 1 homolog
Additionally, both low and high doses of taurine (100 and 400 mg/kg via oral gavage) over nine weeks increased GSH in brain homogenates of mice exposed to D-galactose (22) and improved cognitive deficits in the aging model used in that study
A sulfur-rich natural diet that includes cruciferous vegetables and whole proteins, including grass-fed animal products, helps increase glutathione production, the body's most powerful antioxidant (Figure 3)
2022;11:e74489
The FDA has since approved a higher 2 mg maintenance dose of Ozempic, which was not part of this comparison