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The human CTR was modified to contain an N-terminal Flag tag epitope and a C-terminal 8 histidine tag epitope, each flanked by a HRV 3 C protease cleavage sites

It is sold through research suppliers and compounding contexts, creating variability in oversight and product standards

2024 Jul 25;391(4):311-319.10.1056/NEJMoa2401755 [DOI] [PubMed] 42.Coskun T, Urva S, Roell WC, Qu H, Loghin C, Moyers JS, et al

Add in sleep disruption and changes to your immune response, and you've got a potent recipe for classic hangover symptoms

This profile distinguishes it from corticosteroids like prednisolone, which carry a broader range of potential systemic side effects including increased thirst, frequent urination and behavioral changes