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A study found that vitamin C supplementation (500-1,000 mg/day) increased lymphocyte glutathione by 18% (Lenton et al., Am J Clin Nutr, 2003) [24]

Finally, in the long term, as highlighted in the 20-year follow-up of the DPP (DPPOS, Diabetes Prevention Program Outcomes Study), neither metformin nor lifestyle intervention modified cardiovascular risk [38, 45] in line with previous studies [46,47,48,49]

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