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These side effects were often severe enough to prompt patients to stop their medications

The most modulated genes found through the network approach were SIRT3, FOXO1, and PPARGC1A, these proteins were also found to have the highest docking results, several studies have reported the role of these proteins in the modulation of ROS and oxidative stress via mitochondria, as ROS and oxidative stress have been reported to alter various cellular signaling pathways and cause neuronal death

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[2] Liu, J., Head, E., Gharib, A

Weight Fluctuations: Some individuals have reported unintended weight gain or loss, though evidence on this is limited