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Cariou B, Linge J, Neeland IJ, et al

Reviews To Read February 2026 Published in JAMA Psychiatry by Mehdi Farokhnia and Lorenzo Leggio of the NIDA IRP Clinical Psychoneuroendocrinology and Neuropsychopharmacology Section

The discontinuation of Pfizer's Danuglipron underscores the formidable research and development challenges inherent in this expansive market

Body weight, metabolic status, and concurrent medicationsparticularly those affecting gastrointestinal motility (such as opioids or anticholinergics) or glucose metabolismcan modify both the intensity and duration of adverse effects

Such discoveries may lead to innovative interventions that target not just weight loss, but overall metabolic health