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Interestingly, Igl2 of SR18 also makes hydrophobic interactions with these two residues

Lampropoulos C, Mulita F, Alexandrides T, Kehagias D, Kalavrizioti D, Albanopoulos K, et al

HerSolution may interact with antipsychotics, carbamazepine, estrogen, lithium, SSRIs, triazolam, and valproic acid due to the inclusion of DHEA.7 The DHEA in HerSolution might also worsen psychiatric disorders and increase the risk of mania in those with mood disorders