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The dynamic nature of ECD observed in this study is consistent with previous findings that GLP-1R is equipped with high versatility to recognize a wide range of ligands with distinct chemotypes 40,41 and to participate in diversified receptor activation processes 13,34 (Supplementary Fig

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doi: 10.1016/j.molcel.2018.11.018 69 JinXChenDZhengR-HZhangHChenY-PXiangZ