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In some regions, particularly those with naturally contaminated soil or historical industrial activity, environmental asbestos exposure contributes to an elevated incidence of lung cancer, often diagnosed at younger ages and in both sexes [168,169,170,171,172]

Historia y desarrollo El inters por 5-Amino-1MQ surgi del reconocimiento del papel de la nicotinamida N-metiltransferasa (NNMT) como enzima sobreexpresada en tejido adiposo de modelos de obesidad y en diversos tumores, donde su actividad se vincula con alteraciones del metabolismo de metilos y del NAD+

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In IBS-D patients with elevated serum C4 a borderline increased colonic permeability was found based on urinary mannitol excretion (178)

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