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276 Pathological prion instigates neuronal death, which in turn causes secondary astrocytic reactivity predominantly in the white matter, but the roles of reactive astroglia in prion diseases are poorly understood and hampered by the emerging complexity of astrocyte responses to prion induced pathologies

At standard doses of 1 to 2 mg per day for a 70 kg person, the copper load is approximately 300-fold below the toxic threshold (Pickart & Margolina, 2018)

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Adjusting the dose in paediatric care by dispersing fragments of four different aspirin tablets