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In a recent overview of GLP-1-based therapeutics, Drucker highlighted that newer agents are producing greater and more rapid weight loss, may have important implications for musculoskeletal health, and are now being studied across indications extending beyond diabetes and obesity alone (Figure 1, whereas Figure 2 provides a focused mechanistic schematic of the proposed receptor pharmacology and inflammatory signaling pathways without duplicating the broader clinical integration framework shown in Figure 1