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Together with enzymes like glutathione peroxidase (GPx) and glutathione reductase (GR), it plays a vital role in the body's antioxidant defense system, helping maintain cellular balance and protect against oxidative stress

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The activation of adenylyl cyclase leads to increased intracellular cAMP concentrations, which subsequently activate protein kinase A (PKA) and other downstream effectors including EPAC2 and calcium channels

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Prevalence and characteristics of painful diabetic neuropathy in a large community-based diabetic population in the U.K