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16 However, islet beta-cells can produce and secrete insulin in an incretin-independent manner as long as blood glucose levels are 5mM or higher

Obese patients with PCOS often exhibit increased gonadotropin requirements, a lower yield of retrieved oocytes, a reduced proportion of high-quality embryos, and an elevated risk of ovarian hyperstimulation syndrome (OHSS) during ovulation induction

This slow titration allows the body to adjust comfortably to the medications effects

Side Effects and Safety Considerations GLP-1 receptor agonists are generally well-tolerated, but patients should be aware of potential adverse effects and safety considerations before starting treatment for PCOS

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