Drink Water not Soft Drinks with Artificial Sweeteners New recommendations endorse water over drinks with artificial sweeteners that may contain harmful ingredients and be detrimental over long-term use
Conclusions and future directions The lack of positive effects from CM supplementation within the existing literature is due to a number of factors, including the testing protocols not featuring a predominantly aerobic energy contribution, the lack of testretest reliability of exercise protocols, dosing strategy (i.e., amount and timing), and the recent discovery of quality control issues with some manufacturers stated citrulline:malate ratios
While these dont occur in every case, they are a part of any complete discussion, and this is particularly true for the compound known as trimethylamine-N-oxide ( TMAO )
Some participants reported nausea and diarrhea as the most common side effects, but those were generally mild and easily managed
Now, both drugs are labeled as currently in a shortage by the FDA