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It remains investigational

The mental chatter quiets

Acute effects of dietary carbohydrate restriction on glycemia, lipemia and appetite regulating hormones in normal-weight to obese subjects

Some people may experience a stronger or earlier appetite change on one medicine than the other, but tolerability, side effects, medical history, contraindications, dose stage and individual response matter more than a ranking based on one symptom

Common reactions include: Bloating and gas Diarrhea Decreased appetite Metallic taste in mouth A concern with long-term metformin use is vitamin B12 deficiency [20]