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Efficacy and Safety of OnceWeekly Semaglutide Versus Once-Daily Insulin Glargine as Add On to Metformin (with or without Sulfonylureas) in Insulin-Naive Patients with Type 2 Diabetes (SUSTAIN 4): A Randomised, OpenLabel, Parallel-Group, Multicentre, Multinational, Phase 3a Trial

Skovronsky was rather tentative about the prospects for Zepbound in this indication: That [the SUMMIT trial] was a study with a really strong and profound benefit for patients

A 2023 study published in JAMA found that patients using GLP-1 receptor agonists for weight loss had a significantly higher risk of gastroparesis, pancreatitis, and bowel obstruction compared to those using other weight loss medications

Therefore, if cell lysis due to pore formation by Hld Se was driving GLP-1 release we would have observed toxicity in our studies

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