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Its evidence base is genuinely strong for a trial-stage product two large Phase 3a randomized controlled trials plus a Phase 1b pharmacology study but it has not received marketing approval from any regulator, and its complete benefitrisk profile is still being evaluated

*Correspondence: Juan Huang, [email protected] These authors have contributed equally to this work and share first authorship Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

He isolated GHK from human plasma albumin in 1973 and identified its ability to make old liver tissue synthesize younger protein profiles

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Thus, fibrosis can be decreased by preventing NLRP3 activation in these cells [171, 172]