When someone applies for life insurance after losing weight on GLP-1 medications, underwriters see what looks like a healthy person with: Normal BMI Improved blood pressure Better cholesterol levels Lower HbA1c levels But here's the catch: Research from the landmark STEP 1 trial extension shows that participants regain approximately two-thirds of their prior weight loss within one year of stopping semaglutide (Wilding et al., 2022)
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Cardiovasc Res 113:950961 Schmidt K, Fuchs M, Weber N, Werlein C, Schmitto JD, Ius F et al (2024) Single-nucleus RNA sequencing identifies cell-type-specific effects of sodium-glucose co-transporter 2 inhibitors in human myocardial slices
Over a 1-year time horizon, semaglutide 0.5 mg was 9% less costly than dulaglutide 0.75 mg
This story first appeared on TODAY.com