N-Acetyl Cysteine (NAC) provides the rate-limiting amino acid cysteine for endogenous glutathione synthesis and has been described as a safe intervention for glutathione deficiency (Atkuri et al., 2007)
However, like many peptides, GHK-Cu does not easily cross this barrier
Yang R, Chen Z, Hu P, Zhang S, Luo G (2022) Two-stage fermentation enhanced single-cell protein production by Yarrowia lipolytica from food waste
In recent years independent testing of consumer peptides bought online has repeatedly found a significant proportion failing basic quality checks, with live bacteria, heavy metals and bacterial endotoxin (which can cause serious illness and even death) being present in samples
MPL is formulated in a variety of adjuvant platforms, including AS01 (MPL and QS-21 in phosphatidylcholine liposomes), AS02 (MPL and saponin QS-21 in an oil-in-water emulsion containing squalene and -tocopherol) and AS04 (MPL adsorbed to aluminum oxyhydroxide)