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Ensure adequate fluid intake: A steady fluid intake can help counteract constipation

TJ proteins, such as the claudin family, occludin, Zona occludens 1 (ZO-1), and tricellulin, have been identified as being related to the neuro-barrier [114]

Similarly, deficiencies in thiamine (vitamin B1), vitamin B6, and folate can affect nerve function

19 This effect likely contributes to the decreased risk of stroke in T2D patients receiving treatment with certain GLP-1RAs

If side effects are severe or persistent, healthcare providers may recommend temporarily maintaining the current dose or, in some cases, reducing the dose before attempting further increases