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The rationale for utilizing different conventional B12 supplement at each center, for comparison with Sucrosomial B12, was to ensure the reproducibility of study outcomes amidst the variability in B12 formulations

Heavy alcohol consumption can also contribute to this deficiency

Particularly CYP3A4, the most abundant hepatic oxidase

While the science on whether this local application significantly outperforms systemic is still developing, the anecdotal reports from the research community are what keep this method at the forefront of the conversation

Risk factors include age, vegan diets, certain diseases, and some medicines