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Researchers published this finding On March 6, 2024 in JAMA Surgery

This happened at much higher non-physiologically relevant concentrations than that stimulated by glucagon previously demonstrated by Samols group (Samols, Marri, Marks, 1966)

This is particularly relevant when pairing NAD+ with aesthetic procedures like laser treatments or microneedling adequate NAD+ levels allow cells to respond more effectively to the controlled damage stimulus that drives collagen remodeling in those procedures

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However, indirect factors like dehydration from gastrointestinal side effects can increase susceptibility in some individuals