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Pharmacological management of nutrient-related metabolic disturbances is crucial, as evidenced by the effectiveness of SGLT2 inhibitors such as canagliflozin in lowering the risk of kidney failure and cardiovascular events in patients with type 2 diabetes and established nephropathy (117, 118)

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Islets were then dispersed into single cells with calcium-free Hanks solution and used after incubation for another 24 hours in RPMI media containing either 5.6 mM glucose or 25 mM glucose

Case and control subject selection Cases in the study cohort were defined as patients who experienced incident NAFLD/NASH events during follow-up after cohort entry (i.e., GLA initiation)