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These approaches include the combined use of STING agonists, Nrf2 inhibitors, lactate metabolism blockers, and mitoNIDs, which collectively alleviate immunosuppressive metabolic states, restore T cell function [89,90,91], and improve the responsiveness of MSS CRC to immune ICIs

Perino et al., 2021)

Given the role of endothelial dysfunction in originating cardiovascular diseases, direct analysis of bilirubin in the vascular endothelium would shed light on these relationships

This could indicate that MOR desensitization and tolerance are two unrelated mechanisms

Others point to dehydration, since increased lipolysis generates metabolic water demands