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Abstract Male infertility is a significant global health concern, impacting approximately 15% of couples attempting to conceive, with male-related factors accounting for nearly 50% of these cases

In addition, the inner-mitochondrial-membrane enzyme dihydroorotate dehydrogenase (DHODH) transfers electrons derived from pyrimidine synthesis to ubiquinone, reducing it to ubiquinol and thereby suppressing ferroptosis in parallel with mitochondrial GPX4 (Mao et al., 2021)

Reduces oxidative stress with powerful antioxidant properties

The product of the transamination reactions is 2-oxoglutarate (-ketoglutarate) which can enter the TCA cycle for oxidation