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Pancreatic beta-cell protection : In-vitro research regarding insulin production pathways
In agreement with this, we recently showed that GLP-1-mediated delivery of the PPAR/ co-agonist tesaglitazar (Tesa) decreases body weight and food intake with increased efficacy compared with GLP-1R agonism in DIO mice 26
They solved two major challenges: optimal binding to the GLP-1 receptor and particularly extended circulating half-life, making it both effective and reasonably tolerable
H3 relaxin protects against myocardial injury in experimental diabetic cardiomyopathy by inhibiting myocardial apoptosis, fibrosis and inflammation
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