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Seizures : Some individuals with severe carnitine deficiency, particularly in metabolic disorders, may experience seizures due to impaired brain energy metabolism

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GIP signaling further upregulates the expression of the POMC gene in these neurons and amplifies their intracellular cAMP/protein kinase A (PKA) signaling pathway, thereby enhancing the production of satiety signals

Last Published 01.01.2026 Effective Date: 01.01.2026 This policy addresses apheresis/therapeutic apheresis