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Description

NNMT inhibition increases NAD+ levels and enhances sirtuin-mediated mitochondrial function

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The role of NAD-dependent deacetylase sirtuin-2 in liver metabolic stress through regulating pyruvate kinase M2 ubiquitination

Lead Researcher Spotlight Professor Frank Ng, PhD Department of Biochemistry and Molecular Biology Monash University, Melbourne, Australia Professor Frank Ng led the pioneering research team that developed AOD-9604 in the 1990s as part of efforts to create a targeted anti-obesity therapeutic derived from human growth hormone

doi: 10.1186/s12958-019-0509-4