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Reactive oxygen species, such as hydrogen peroxide (HO), can be neutralized by GSH peroxidases, which catalyze the conversion of HO into water (HO) while oxidizing GSH to GSSG

All therapeutic applications remain investigational, and long-term human safety data are absent from the published literature

After its synthesis, GSH is delivered to some intracellular compartments, including mitochondria, endoplasmic reticulum, nucleus, and to the extracellular space (e.g., blood plasma and bile) for utilization by other cells and tissues (Forman et al., 2009)