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Deregulated activation of c-Met contributes to a few aspects of tumor progression, such as inducing neoplastic cells to disaggregate from the tumor mass, eroding basement membranes, infiltrating stromal matrices, and finally colonizing new tissues to form metastases ( Onset Chronic liver diseases such as cirrhosis and hepatitis B or C are triggers of HCC ( N -nitrosodiethylamine-induced HCC (Takami et al., 2007)

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[223] and LaRochelle et al