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Cachexia causes severe weakness, weight loss, fatigue, and poor quality of life

The authors would like to note that this work reflects only one type of biomolecule and other biomolecules may not yield the same effect

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doi:10.1136/bmj.325.7373.1164

Animal models, while more physiologically complex, are expensive, ethically constrained, and often poorly predictive of human pathophysiology, contributing to translational failure ( OoC platforms provide a human-relevant alternative by enabling the assessment of drug efficacy, toxicity, and pharmacokinetics under dynamic, physiologically inspired conditions