The major food groups tested in the experiment were cereal products, legumes, and meats
Some of these adverse effects reported were Toxic Epidermal Necrolysis (a rare but life-threatening skin condition characterized by painful blisters and large areas of skin peeling), air embolism, thyroid dysfunction, and liver, kidney, and neurologic toxicity (The dark side of skin lightening- PubMed) With the proliferation of med-spas in an unregulated fashion, there is a risk of inadequately trained or untrained people giving IV injections in a non-sterile way, which can lead to sepsis and transmission of infections like HIV and hepatitis
& New, EJ Reversible fluorescent probes for biological redox states
Several factors can contribute to hyperpigmentation, such as long hours under the sun (leading to sun spots), acne scars from previous breakouts, and hormonal changes that are often seen during pregnancy or using birth control
J Biol Chem 276(23):2008520092