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Prolotherapy uses irritant solutions (often hypertonic dextrose) to stimulate local healing , recruit cells, and modulate pain
Nephrol Dial Transpl
Essentially, it works by inhibiting the production of tyrosinase, an enzyme that triggers melanin production
Pike AF, Longhena F, Faustini G, van Eik JM, Gombert I, Herrebout MAC, et al
