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NADPH in Detoxification The liver is the major organ for the detoxification of endogenous and exogenous (xenobiotic) compounds

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In a double-blind, placebo-controlled trial in 11 smokers and 13 nonsmokers given -tocopherol and -tocopherol that was labeled with deuterium, supplementation with vitamin C reduced the rate of vitamin E loss in plasma, likely by regenerating tocopheryl radicals back to nonoxidized forms (22)