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Moreover, real-world evidence derived from the US Collaborative Network of TriNetX, which analyzed data from individuals with T2DM aged 18 years who initiated tirzepatide or a GLP-1 RA between June 1, 2022, and June 30, 2023, suggests that tirzepatide reduces the risk of all-cause mortality by 42%, MACE by 20%, and major adverse kidney events by 46% [84]

Genetics may play a role, but the differences seen in studies dont fully explain the wide range of responses we see in clinical practice, she says

The glucagon receptor in retatrutide promotes fat oxidation specifically, which theoretically shifts the fat-to-lean-mass loss ratio more favorably

Gomez LA, Heath SH, Hagen TM