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Identification of vitamin B12 as a modulator of LRRK2 activity constitutes a huge step forward because it is a neuroprotective vitamin in animal models and has a mechanism unlike that of currently existing inhibitors, Iban Ubarretxena, director of the Biofisika Institute and co-author of the study, said in a press release

It ensures the testing results are objective and reliable for research use

Maintaining improvements long-term requires either continued use or transition to lifestyle interventions that sustain AMPK activation (resistance training, caloric cycling)

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