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In this research, we showed that ferrostatin-1 can prevent A-like aggregation, restore ferritin levels, and decrease lipid peroxidation in brain organoids derived from human AD iPSCs

In addition, GRP78 is normally located in the ER at low levels, and its expression (but not its functional rate) may be upregulated by calcium ionophores, calcium depletors or chelators, and inhibitors of the protein secretory pathway ( in silico with possible benefits in ER stress-related tumor treatment (Wang H

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