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[11] The Gut-Skin Axis: A Validated Biological Framework A 2023 review in Nutrients examining the role of probiotics in skin health through the gut-skin axis identified multiple mechanisms through which gut-acting probiotics influence skin outcomes: decreasing oxidative stress, modulating inflammatory cytokine production, and supporting immune responses that govern microbial balance on the skin surface

(B) Hazard ratios and 95% CIs for all-cause and cardiovascular mortality according to ACR for people with diabetes (red) and without (blue)