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Abbreviations Alg: Sodium alginate AMNP: Allogenic melanin nanoparticles BG: Beta-glucan BME: Biofilm microenvironment BNN6: N,N-dis-sec-butyl-N,N-dinitroso-1,4-phenylenediamine CaCO 3 : Calcium carbonate sGC: Soluble guanylate cyclase cGMP: Cyclic guanosine monophosphate CMC: Carboxymethyl chitosan CNO: Cysteine-NO CS: Chitosan CysNO: S-nitrosocysteine CuS: Copper sulfide DFUs: Diabetic foot ulcers e-CSE: Electronic cigarette extract eNOS: Endothelial nitric oxide synthase EPT: Enzyme prodrug therapy GO: Graphene oxide GSH: Glutathione Cel2-NO: Cellobioside diazeniumdiolate dinitrol Cel5A-h38: Endocellulase GSNO: S-nitrosoglutathione H&E: Hematoxylin & eosin HIF-1: Hypoxia-inducible factor-1 H 2 O 2 : Hydrogen peroxide HKUST-1: Organic copper skeleton HBPL-MnO: Hyperbranched poly-l-lysine modified manganese dioxide 4-MAP: 4-(Pyridinemethaneamine) L-Arg: L-arginin IGF-1: Insulin-like growth factor-1 iNOS: Inducible nitric oxide synthase ISDN: Isosorbide dinitrate MN: Micro-needle mNOS: Mitochondrial nitric oxide synthase MOF: Metal-organic framework MRSA: Methicillin-resistant Staphylococcus aureus NADPH: Nicotinamide adenine dinucleotide phosphate NIR: Near-infrared nNOS: Neuronal nitric oxide synthase NO: Nitric oxide NO 2 : Nitrogen dioxide NOD-NPs: Hydrophilic nanoparticles NOHLA: N -hydroxy-L-arginine NONOates: N-diazeniumdiolates NOS: Nitric oxide synthase SNAP: S-nitroso-N-acetylpenicillamine GelMA: Gelatin methacrylate HO: Hydroxyl radical PAs: Proanthocyanidins PB: Prussian blue Pd: Palladium PDA: Polydopamine PEGDA: Polyethylene glycol diacrylate PEI: Polyvinylimide PLLA: Polylactic acid PLGA: Poly(lactic-co-glycolic acid) RNS: Reactive nitrogen species RONO 2 : Organic nitrates ROS: Reactive oxygen species RSNOs: S-nitrosothiols SDF: Stromal cell derived factor UV: Ultraviolet VEGF: Vascular endothelial growth factor XOR: Xanthine oxidoreductase References Zahid AA, Augustine R, Dalvi YB, Reshma K, Ahmed R, Rehman SRU, Marei HE, Alfkey R, Hasan A

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Allaire JM, Crowley SM, Law HT et al (2018) The intestinal epithelium: central coordinator of mucosal immunity