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We use variants of the peptides GLP-1 and exendin-4 (Ex4) to explore the interplay between helical propensity near the agonist N terminus and the ability to bind to and activate the receptor
Reduced binding to IGF-binding proteins allows prolonged receptor engagement, ensuring sustained signaling in in vitro and preclinical research models
lack of stomach acid is not the only factor that can effect the absorption of vitamin B12 (thinking here of inborn errors of metabolism, resection of the ileum) so suitability may depend on the cause of the B12 deficiency
The LC-MS/MS analysis was performed using a Sciex QTRAP 6500 + - MS connected to a Sciex AD UHPLC
J.JavadovS
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