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In contrast, the reduction in TIM23 combined with normalization of TOM40 in NAM-pre-treated neurons may indicate partial recovery of mitochondrial mass and remodelling of mitochondrial shape

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Another reading suggests that broad gene-expression effects can reflect secondary consequences (changes in cell state, in proliferation rate, in metabolism) rather than direct mechanism-based effects, and that the specificity of the transcriptomic findings should be interpreted with caution

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Alongside controlling hunger, GLP-1 injections support steady energy levels