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Funding This work was supported by funding from the Natural Science Foundation of Hunan Province (No

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These effects were consistent across participants aged 65 and 60 years with obesity or overweight and at least one weight-related comorbidity experienced a 510% reduction in baseline body weight following 24 weeks of liraglutide treatment, although body composition was not assessed in this study [44]

This distinction may influence whether natural alternatives alone are sufficient or whether compounded GLP-1 or tirzepatide would offer more effective support within a comprehensive plan