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The MHRA has not licensed these drugs for dermatological conditions, and they are not included in NICE guidelines (CG153) for psoriasis management

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The dose dependent interactions between these medications create dangerous cross tolerance effects, potentially leading to severe respiratory depression

Gut 69(12):22322243 Herath M, Hosie S, Bornstein JC, Franks AE, Hill-Yardin EL (2020) The role of the gastrointestinal mucus system in intestinal homeostasis: implications for neurological disorders

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