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Inflammation in the brain is characterized by the activation of glial cells (oligodendrocytes, astrocytes, microglia and ependymal cells) and the production of cytokines, chemokines, prostaglandins, nitric oxide (NO), reactive oxygen species (ROS), and immune cell infiltration, including monocytes/macrophages, neutrophils, dendritic cells, T cells, and B cells

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Topical Copper Peptides Affects surface layers of skin only Limited penetration through skin barrier Localized effect only where applied Good for maintenance, not transformation No systemic anti-aging benefit Available over-the-counter Injectable GHK-Cu Full systemic delivery to all tissues Reaches dermis, follicles, and healing sites Whole-body anti-aging effect More potent collagen stimulation Gene expression modulation (4,000+ genes) Requires medical prescription They are not mutually exclusive

doi: 10.3390/cells13131145 133 WuYLiXMengHWangYShengPDongYet al

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