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Defects in SDH subunits lead to succinate accumulation and oncometabolite-driven pseudohypoxia and are strongly linked to hereditary paragangliomas, pheochromocytomas and certain renal cell carcinomas, underscoring the essential role of complex II in metabolic and redox homeostasis 78,79

Graziani, G

Enzyme Cofactor: Supports antioxidant and detox pathways through enzymes such as glutathione peroxidases and glutathione S-transferases

L-cysteine supplementation also helps to prevent the downregulation of vitamin D regulatory genes by way of increasing GSH N-Acetylcysteine (NAC) is another form of cysteine that is considered less toxic, less susceptible to oxidation (and dimerization) and is more soluble in water, making it a better source of cysteine than parenteral administration of cysteine itself. GSH is necessary to help protect our cells from damage due to oxidative stress, mercury and other toxic metals, alcohol, persistent organic pollutants, and much more

At Cymbiotika, we focus on science-backed formulations that prioritize bioavailability