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Rather than representing a purely cutaneous condition, PsO appears to be a systemic metabolicinflammatory disease in which insulin resistance, adipokine imbalance, and altered gutendocrine signaling contribute to immune dysregulation long before the onset of clinically overt joint involvement (7)

Virus-hijacked host cellular factors Clinical outcomes of COVID-19 are directly related to the ability of the SARS-CoV-2 pathogen to hijack host metabolic machinery as well as cellular factors of an infected individual, for viral invasion and internalization, followed by intra-cellular replication to assemble and release multiple viral copies for ultimate propagation/transmission

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It became fuel, it became mechanical