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The Jastreboff trial demonstrated a 42% relative reduction in hepatic fat content (MRI-PDFF measured) in the 8mg and 12mg retatrutide arms versus 2% with placeboa magnitude not seen with semaglutide or tirzepatide monotherapy in comparable populations

GLP-1, or glucagon-like peptide-1, is a hormone that regulates blood sugar levels and appetite

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The trial concluded that the medication supported substantial and sustained weight loss, as quoted from the study findings, when combined with lifestyle changes

[1] Side Effects of Compounded* Semaglutide Nausea, vomiting, diarrhoea, constipation and stomach pain are the most common side effects of GLP-1 medications