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An important clarification: this compound is technically a small molecule, not a peptide

In response to androgen stimulation, PCa cells recruit and activate CAFs, which significantly enhance the size of PC organoids by remodeling the ECM ( Cancer cells phenotypes and molecular functions are intrinsically tied to signals originating from outside the cell, particularly through interactions with ECM (Winkler et al., 2020)

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The overall anti-inflammatory action of adiponectin involves the inhibition of NF-B activation and production pro-inflammatory cytokine IL-6 and the induction of the expression of anti-inflammatory IL-10 [142,143]

The hazard ratio for all-cause mortality was 0.94 (95% CI: 0.78-1.13)