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Abstract Many local and systemic diseases especially diseases that are leading causes of death globally like chronic obstructive pulmonary disease, atherosclerosis with ischemic heart disease and stroke, cancer and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing coronavirus disease 19 (COVID-19), involve both, (1) oxidative stress with excessive production of reactive oxygen species (ROS) that lower glutathione (GSH) levels, and (2) inflammation

J Am Geriatr Soc 69(8):23272334 Appari M, Channon KM, McNeill E (2017) Metabolic regulation of adipose tissue macrophage function in obesity and diabetes

Fourth, a number of patients withdrew from the study but no causal association can be determined

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Applications: Anti-aging therapies, prevention of age-related diseases, and longevity enhancement