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In the 2026 ADA Scientific Sessions, results from the Phase-3 TRANSCEND-T2D-1 study involving retatrutide, a triple agonist of GLP-1, GIP, and glucagon receptors, showed up to a 2% decrease in A1C and a 16.8% decrease in body weight over 40 weeks in patients with type 2 diabetes

It is important to note that whilst these changes are statistically significant in large trials, the clinical significance for individual patients remains modest compared to dedicated lipid-lowering therapies such as statins

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